By J. L. Vincent (auth.), Edward Abraham MD, Mervyn Singer MD (eds.)
There were great advances in figuring out the mobile mechanisms occupied with sepsis and contributing to the advance of a number of organ disorder and mortality during this atmosphere. The chapters during this ebook offer up to date insights into very important pathways which are initiated through sepsis.
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There were great advances in realizing the mobile mechanisms interested by sepsis and contributing to the improvement of a number of organ disorder and mortality during this atmosphere. The chapters during this ebook supply updated insights into very important pathways which are initiated by way of sepsis.
Additional info for Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery
Arbour NC, Lorenz E, Schutte BC, et al. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25:187–191 50. Lorenz E, Mira JP, Frees KL, Schwartz DA (2002) Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 162:1028–1032 51. Child NJ, Yang IA, Pulletz MC, et al (2003) Polymorphisms in Toll-like receptor 4 and the systemic inﬂammatory response syndrome. Biochem Soc Trans 31:652–653 52. Emonts M, Hazelzet JA, de Groot R, Hermans PW (2003) Host genetic determinants of Neisseria meningitidis infections.
Interestingly, similar susceptibility to S. aureus infection and tuberculosis have been reported in human populations carrying TLR2 polymorphisms [16–20]. Identiﬁcation of the effects in such human states validates the use of murine knockout models to identify key pathways controlling predisposition to infection. Studies in twins have also provided arguments for ‘genetically programmed’ susceptibility to infection, when homozygous twins who have the same genome are compared with heterozygous twins who are genetically different.
Curr Opin Crit Care 10:318–324 65. Mira JP, Cariou A, Grall F, et al (1999) Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study. JAMA 282:561–568 66. Hedberg CL, Adcock K, Martin J, Loggins J, Kruger TE, Baier RJ (2004) Tumor necrosis factor alpha – 308 polymorphism associated with increased sepsis mortality in ventilated very low birth weight infants. Pediatr Infect Dis J 23:424–428 67. Gordon AC, Lagan AL, Aganna E, et al (2004) TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study.