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Download Hormonal Control of Cell Cycle (Research and Perspectives in by Shlomo Melmed, Henri Rochefort, Philippe Chanson PDF

By Shlomo Melmed, Henri Rochefort, Philippe Chanson

This publication covers themes that diversity from basic reviews of DNA replication, chromosomal and nuclear functionality via progress issue keep watch over of endocrine tumor initiation and development. the elemental and translational insights won from Hormonal keep watch over of telephone Cycle can be of curiosity to these learning the biology of endocrine tumors in addition to these deriving novel healing methods for those benign and malignant issues.

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New York: Raven Press pp 59–76 Pestell RG, Albanese C, Reutens AT, Segall JE, Lee RJ, Arnold A (1999) The cyclins and cyclindependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocrine Rev 20:501–534 Reutens AT, Fu M, Wang C, Alvanese C, McPhaul MJ, Sun Z, Balk SP, Janne OA, Palvimo JJ, Restell RG (2001) Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner. Mol Endocrinol 15:797–811 Sakamaki R, Casimiro MC, Ju X, Quong AA, Katiyar S, Liu M, Jiao X, Li A, Zhang X, Lu Y, Wang C, Byers S, Nicholson R, Link T, Shemluck M, Yang J, Fricke ST, Novikoff PM, Papanikolaou A, Arnold A, Albanese C, Pestell R (2006) Cyclin D1 determines mitochondrial function in vivo.

In contrast, these cells require the induction of cell stress to proliferate in response to IGF-I. Hyperglycemia serves as a model of cell stress in this test system. Cells exposed to 25 mM glucose will double in number in response to IGF-I within 48 hr whereas cells exposed to 5 mM glucose do not proliferate. There are two important determinants of the ability of these cells to respond to IGF-I with an increase in proliferation. The first is that the signaling protein, Shc, must be recruited to the cell membrane and phosphorylated.

The role of the cyclins and CDKs in development through mutagenesis and deletional analysis in mouse models was recently reviewed (Sridhar et al. 2005). Importantly, genetic deletional analysis in the mouse has suggested an important role for a subset of the cyclins and CDKs in hormone signaling and normal physiological responses. In this regard the cyclin D1−/ − mice, in addition to being smaller than their littermate controls, show abnormalities of breast development during lactation as well as altered lipogenesis.

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