Download Current Diagnosis & Treatment in Infectious Diseases by Walter Wilson, Merle Sande PDF

By Walter Wilson, Merle Sande

The world over popular infectious affliction specialists provide suggestions in spotting, diagnosing, treating, and fighting one of many best explanations of demise world wide. Clinically concentrated and complete, the publication covers the necessities of analysis and syndromes in young children and adults. Examines antimicrobial resistance and balances specialist, practice-oriented assurance with simply the correct amount of microbiology strategies. (20020301)

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Macrolides and beta-lactam drugs with the possible exception of ticarcillin, which may cause teratogenic effects in rodents, may be administered safely to pregnant females. Tetracycline use should be avoided in pregnant women as mentioned above. In addition, the administration of tetracycline intravenously has been associated with acute fatty necrosis of the liver in pregnant women. Streptomycin may cause vestibular or ototoxic damage to the fetus. Most antimicrobial agents administered to women may be detected in the breast milk of nursing mothers, although their concentrations in breast milk are usually low.

Outbreaks of diphtheria may result from corynephage infection of nontoxigenic Corynebacterium diphtheriae strains within hosts and the conversion of these strains to toxin producers after phage delivery of the diphtheria toxin gene (see Chapter 51). The same type of event appears to be responsible for the dissemination of Shiga-like toxin genes among otherwise harmless Escherichia coli serotypes and the subsequent creation of enterohemorrhagic strains. Furthermore, recent data indicate that fluoroquinolone exposure may boost Shiga-like toxin production by these phage-infected strains through phage regulatory pathways and, therefore, may be detrimental to the host.

Additionally, one should review carefully other medications administered concomitantly. Numerous drug interactions with antimicrobial agents have been reported. These may result in decreased absorption of orally administered antimicrobial agents or may result in or potentiate serious drug toxicity resulting from the concomitant drug, the antimicrobial agent, or both. The potential drug interactions are so numerous and newly described interactions are reported so frequently that it is difficult, if not impossible, for the practicing physician to be aware of all of these interactions.

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