By Philipp Haus-Seuffert, Michael Meisterernst (auth.), Heinz Rupp, Bernard Maisch (eds.)
The unique factor of Molecular and mobile Biochemistry makes a speciality of `Control of Gene Expression via Catecholamines and the Renin-Angiotensin approach' in well-being and sickness. lately, nice growth has been made within the realizing of catecholamine and angiotensin II modulated gene expression. there's additionally expanding facts that catecholamine and angiotensin II precipitated mobile damage no longer exclusively arises from classical pathways but in addition from a perturbed gene expression.
bearing in mind that catecholamines and angiotensin II are very important for a balanced gene expression of many cells, the exciting danger arises that quite a few sickness are initiated or annoyed through such an imbalance. Catecholamine and angiotensin II impacts will be in extra coming up from, for instance, hypercaloric nutrition consumption or psychosocial pressure. in the course of early development of center failure, sympathetic task and angiotensin II impacts additionally develop into elevated. because of beta-adrenergic receptor downregulation, depressed catecholamine affects are anticipated within the ultimate degree of center failure. An imbalanced effect of catecholamines and angiotensin II on gene expression ends up in disordered molecular constructions of the telephone and an impaired telephone functionality.
This targeted factor is equipped into chapters targeting catecholamines, angiotensin II, and the interplay among catecholamines and angiotensin II. uncomplicated biochemical techniques are lined intimately and the potential for those pathways for explaining continual illnesses linked to extra catecholamine and angiotensin II affects may still develop into obvious. it really is was hoping that this focussed factor triggers novel examine into the advance of substances which are exact at illnesses characterised by way of an imbalanced gene expression regarding catecholamines and angiotensin II.
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2000 Kluwer Academic Publishers. Attenuation of macrophage apoptosis by the cAMP-signaling system Andreas von Knethen and Bernhard Brune Department of Medicine IV-Experimental Division, Faculty of Medicine, University of Erlangen-Niirnberg, Germany Abstract Previous studies revealed that expression and activation of cyclooxygenase-2 (Cox-2) conveyed a protective principle in murine macrophages, thus attenuating pro-apoptotic actions of chemotherapeutic agents or programmed cell death as a result of massive nitric oxide (NO) generation.
Brockhaus F, Briine B: U937 apoptotic cell death by nitric oxide: Bel2 downregulation and caspase activation. Exp Cell Res 238: 33-41, 1998 13. May P, May E: Twenty years ofp53 research: Structural and functional aspects ofthe p53 protein. Oncogene 18: 7621-7636,1999 14. Agarwal ML, Taylor WR, Chernov MY, Chernova OB, Stark GR: The p53 network. J Bioi Chern 273: 1-4, 1998 15. LevineAJ: p53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997 16. Watson RW, Redmond HP, Bouchier-Hayes D: Role of endotoxin in mononuclear phagocyte-mediated inflammatory responses.
Proc Nat! Acad Sci USA 92: 5855-5859, 1995 12. Roesler WJ, Vandenbark GR, Hanson RW: Cyclic AMP and the induction of eukaryotic gene transcription. J BioI Chern 263: 9063-9066, 1988 13. Park YG, Nesterova M, Agrawal S, Cho-Chung YS: Dual blockade of cyclic AMP responsive element-(CRE) and AP-l-directed transcription by CRE-transcription factor decoy oligonucleotide. J BioI Chern 274: 1573-1580, 1999 14. Montminy MR, Bilezikjian LM: Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene.