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Download Control of Gene Expression by Catecholamines and the by Philipp Haus-Seuffert, Michael Meisterernst (auth.), Heinz PDF

By Philipp Haus-Seuffert, Michael Meisterernst (auth.), Heinz Rupp, Bernard Maisch (eds.)

The unique factor of Molecular and mobile Biochemistry makes a speciality of `Control of Gene Expression via Catecholamines and the Renin-Angiotensin approach' in well-being and sickness. lately, nice growth has been made within the realizing of catecholamine and angiotensin II modulated gene expression. there's additionally expanding facts that catecholamine and angiotensin II precipitated mobile damage no longer exclusively arises from classical pathways but in addition from a perturbed gene expression.
bearing in mind that catecholamines and angiotensin II are very important for a balanced gene expression of many cells, the exciting danger arises that quite a few sickness are initiated or annoyed through such an imbalance. Catecholamine and angiotensin II impacts will be in extra coming up from, for instance, hypercaloric nutrition consumption or psychosocial pressure. in the course of early development of center failure, sympathetic task and angiotensin II impacts additionally develop into elevated. because of beta-adrenergic receptor downregulation, depressed catecholamine affects are anticipated within the ultimate degree of center failure. An imbalanced effect of catecholamines and angiotensin II on gene expression ends up in disordered molecular constructions of the telephone and an impaired telephone functionality.
This targeted factor is equipped into chapters targeting catecholamines, angiotensin II, and the interplay among catecholamines and angiotensin II. uncomplicated biochemical techniques are lined intimately and the potential for those pathways for explaining continual illnesses linked to extra catecholamine and angiotensin II affects may still develop into obvious. it really is was hoping that this focussed factor triggers novel examine into the advance of substances which are exact at illnesses characterised by way of an imbalanced gene expression regarding catecholamines and angiotensin II.

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2000 Kluwer Academic Publishers. Attenuation of macrophage apoptosis by the cAMP-signaling system Andreas von Knethen and Bernhard Brune Department of Medicine IV-Experimental Division, Faculty of Medicine, University of Erlangen-Niirnberg, Germany Abstract Previous studies revealed that expression and activation of cyclooxygenase-2 (Cox-2) conveyed a protective principle in murine macrophages, thus attenuating pro-apoptotic actions of chemotherapeutic agents or programmed cell death as a result of massive nitric oxide (NO) generation.

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