By Professor Dietmar Schomburg, Dr. Ida Schomburg, Dr. Antje Chang (eds.)
Springer instruction manual of Enzymes presents facts on enzymes sufficiently good characterised. It bargains concise and entire descriptions of a few 5,000 enzymes and their software parts. information sheets are prepared of their EC-Number series and the volumes themselves are prepared in accordance with enzyme classes.
This new, moment variation displays huge development in enzymology: many enzymes are newly categorised or reclassified. each one access is correlated with references and a number of resource organisms. New datafields are created: software and engineering (for the homes of enzymes the place the series has been changed). the full volume of fabric inside the guide has greater than doubled in order that the whole moment variation comprises 39 volumes in addition to a Synonym Index. moreover, beginning in 2009, all newly categorized enzymes are taken care of in complement Volumes.
Springer guide of Enzymes is a perfect resource of data for researchers in biochemistry, biotechnology, natural and analytical chemistry, and nutrients sciences, in addition to for medicinal applications.
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Additional info for Class 2 Transferases: EC 188.8.131.52–184.108.40.206
1 the enzyme is required to link the yeast pheromone response G-protein b g subunits to downstream signalling components ; <211> the enzyme is necessary for mating ; <210> Pak1 protein is likely to be an effector for Cdc42p or a related GTPase, Pak1p may be involved in the maintenance of cell polarity and in mating ; <209> the enzyme is involved in budding and cytokinesis and interacts with Cdc42, a GTPase required for polarized cell growth ; <214> hPAK1 is a GTPase effector controlling a downstream MAP kinase pathway.
E. ) [424, 427, 430, 431, 432, 438, 441] P ADP + O-phospho-[tau-protein] S ATP + a protein <2, 151, 153, 155, 156, 157, 162, 163, 164, 165, 170, 240, 241, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 256, 257, 258, 259, 266, 271, 275, 276, 277, 278, 281, 282> (<153> the enzyme is essential for viral replication ; <162,163> not essential for cell viability ; <163> Cki2, may contribute to the regulation of cell morphology ; <157> the enzyme is a regulator of DNA strand-break repair ; <164,165> enzyme is involved in the regulation of DNA repair ; <155,156> enzyme plays a pivotal role in eukaryotic cell regulation ; <151> gene disruption reveals that cki3+ is dispensable for cell viability, and cells lacking functional cki3+ exhibit no characteristic phenotype ; <170> casein kinase 1 a gene is developmentally regulated and the kinase activity of the protein is induced by DNA damage.
Possible requirement in mechanisms associated with DNA repair during early embryogenesis ; <277> Pkn5 negatively regulates Myxococcus xanthus development ; <281,282> AfsK plays a regulatory role in aerial mycelium formation in Streptomyces griseus ; <277,278> expressed constitutively throughout the life cycle, with slight increases at an early stage of development ; <276> the enzyme blocks the secretion of b-lactamase by phosphorylation ; <275> pknA is required for both normal cellular growth and differentiation ; <278> Pkn6 may be a transmembrane sensor of external signals for development ; <281> involvement of afsK in the regulation of secondary metabolism ; <241> the enzyme is required to promote the activity of at least six distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression ; <240> the enzyme is a negative regulator of both sexual conjugation and meiosis ; <243> STK1 mostly affects a loweraffinity, low-capacity polyamine transport activity ; <244> enzyme is not essential for vegetative growth ; <246> the SKS1 protein kinase is a multicopy suppressor of the snf3 mutation of Saccharomyces cerevisiae ; <245> the enzyme enhances spermine uptake in Saccharomyces cerevisiae ; <248, 249> in some cancers displaying chromosomal instability the loss of this checkpoint is associated with the mutational inactivation of a human homologue of the yeast BUB1 gene ; <250> the enzyme is essential for the fission yeast spindle checkpoint response to spindle damage and to defects in centromere function.