Download Chemical Genomics: Small Molecule Probes to Study Cellular by Stefan Jaroch (Editor), Hilmar Weinmann (Editor) PDF

By Stefan Jaroch (Editor), Hilmar Weinmann (Editor)

Chemical genomics is a hugely interdisciplinary and extremely intriguing box of study either in lecturers and within the existence sciences undefined. The Ernst Schering learn beginning Workshop fifty eight was once prepared to compile medical leaders within the box to debate the results of chemical genomics for drug discovery. a variety of features of the interface among chemistry and biology are lined during this quantity, corresponding to chemogenomics efforts within the pharmaceutical undefined, diversity-oriented synthesis, chemogenomic methods to the research of mobilephone functionality, screening applied sciences, and normal items as instruments in chemical biology.

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40 41 45 45 Abstract. G-protein coupled receptors (GPCRs) are promising targets for the discovery of novel drugs. In order to identify novel chemical series, highthroughput screening (HTS) is often complemented by rational chemogenomics lead finding approaches. We have compiled a GPCR directed screening set by ligand-based virtual screening of our corporate compound database. This set of compounds is supplemented with novel libraries synthesized around proprietary scaffolds.

Screening of the five scaffold libraries provided a chemical lead series with an excellent profile: (a) nanomolar functional activity in the functional in vitro assay, (b) nanomolar affinity in a radioligand binding assay, (c) submicromolar activity in a secondary Chemogenomics Approaches to Lead Finding 41 chemotaxis assay, (d) good solubility, and (e) excellent pharmacokinetic properties. Further chemical optimization of this series toward a clinical candidate is currently ongoing. As for the purinergic GPCRs libraries, subsets of these libraries targeting peptide and chemokine receptors have been profiled against a set of 15 GPCRs using radioligand displacement assays.

Annu Rep Med Chem 35:289–298 Rival Y, Hoffmann R, Didier B, Rybaltchenko V, Bourguignon J-J, Wermuth CG (1998) 5-HT3 Antagonists derived from aminopyridazine-type muscarinic M1 agonists. J Med Chem 41:311–317 Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM (1998) Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.

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