Chemical

Download Chemical Genomics: Small Molecule Probes to Study Cellular by Stefan Jaroch (Editor), Hilmar Weinmann (Editor) PDF

By Stefan Jaroch (Editor), Hilmar Weinmann (Editor)

Chemical genomics is a hugely interdisciplinary and extremely intriguing box of study either in lecturers and within the existence sciences undefined. The Ernst Schering learn beginning Workshop fifty eight was once prepared to compile medical leaders within the box to debate the results of chemical genomics for drug discovery. a variety of features of the interface among chemistry and biology are lined during this quantity, corresponding to chemogenomics efforts within the pharmaceutical undefined, diversity-oriented synthesis, chemogenomic methods to the research of mobilephone functionality, screening applied sciences, and normal items as instruments in chemical biology.

Show description

Read Online or Download Chemical Genomics: Small Molecule Probes to Study Cellular Function (Ernst Schering Research Foundation Workshop 58) PDF

Best chemical books

Membrane Handbook

Membrane methods have large commercial ap­ This instruction manual reports the printed litera­ plications protecting many present and rising ture, offers an in-depth description of com­ makes use of within the chemical, petrochemical, petroleum, mercialized membrane methods, and offers a cutting-edge overview of latest membrane seasoned­ environmental, water therapy, pharmaceutic­ al, scientific, nutrients, dairy, beverage, paper, tex­ cess techniques less than improvement.

Nonlinear Laser Chemistry: Multiple-Photon Excitation

Prefaces tend to be written whilst a manuscript is done. Having entire this booklet i will be able to truly see many shortcomings in it. but when i started to put off them i'd most likely write particularly a special booklet in one other years; certainly, this has already occurred as soon as. In 1979, whilst i stopped the 1st model of this booklet, it used to be a lot broader in scope and was once to be titled "Laser Photochemistry.

Chemical Carcinogenesis

In the course of October 18-30, 1981, the second one process the foreign institution of natural and utilized Biostructure, a NATO complex examine Institute, was once held on the Ettore Majorana middle for medical tradition in Erice, Italy, co-sponsored by way of the overseas Union opposed to melanoma, the Italian League opposed to melanoma, the Italian Ministry of Public schooling, the Italian Ministry of medical and Technological study, the North Atlantic Treaty association, the Italian nationwide study Council, the Sicilian neighborhood executive and pharmaceutical businesses (Zambeletti and Farmitalia).

Additional info for Chemical Genomics: Small Molecule Probes to Study Cellular Function (Ernst Schering Research Foundation Workshop 58)

Example text

40 41 45 45 Abstract. G-protein coupled receptors (GPCRs) are promising targets for the discovery of novel drugs. In order to identify novel chemical series, highthroughput screening (HTS) is often complemented by rational chemogenomics lead finding approaches. We have compiled a GPCR directed screening set by ligand-based virtual screening of our corporate compound database. This set of compounds is supplemented with novel libraries synthesized around proprietary scaffolds.

Screening of the five scaffold libraries provided a chemical lead series with an excellent profile: (a) nanomolar functional activity in the functional in vitro assay, (b) nanomolar affinity in a radioligand binding assay, (c) submicromolar activity in a secondary Chemogenomics Approaches to Lead Finding 41 chemotaxis assay, (d) good solubility, and (e) excellent pharmacokinetic properties. Further chemical optimization of this series toward a clinical candidate is currently ongoing. As for the purinergic GPCRs libraries, subsets of these libraries targeting peptide and chemokine receptors have been profiled against a set of 15 GPCRs using radioligand displacement assays.

Annu Rep Med Chem 35:289–298 Rival Y, Hoffmann R, Didier B, Rybaltchenko V, Bourguignon J-J, Wermuth CG (1998) 5-HT3 Antagonists derived from aminopyridazine-type muscarinic M1 agonists. J Med Chem 41:311–317 Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM (1998) Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.

Download PDF sample

Rated 4.21 of 5 – based on 23 votes