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By S. Ehrenpreis

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Ther. 1 5 6 , 3 1 . B i g g e r s , J . , G w a t k i n , R. B . L . , a n d M e y n e r , S . ( 1 9 6 1 ) . Exp. Cell Res. 2 5 , 4 1 . B l a c k , I. B . , H e n d r y , I . , a n d Iversen, L . L . ( 1 9 7 2 ) . / . Neurochem. 1 9 , 1367. B l a s c h k o , H . ( 1 9 3 9 ) . / . Physiol. (London) 9 6 , 50. B o g d a n s k i , D . E . , a n d B r o d i e , Β . B . ( 1 9 6 8 ) . Life Sei. 7 , 4 1 9 . , a n d Molinoff, P. B . ( 1 9 7 1 ) . / . Pharmacol. Exp. Ther. 1 7 8 , 4 1 7 . B r o d i e , B .

2 9 , 1 9 2 9 . J o h n s o n , D . , a n d K o p i n , I. J . ( 1 9 7 1 ) . / . Neurochem. 1 8 , 2355. J o h n s o n , D . G . , Silberstein, S. D . , a n d K o p i n , I . J . ( 1 9 7 2 ) . / . Neuro­ chem. 1 9 , 2 0 2 5 . K a t z , R. , a n d K o p i n , I . J . ( 1 9 6 9 ) . / . Pharmacol. Exp. Ther. 1 6 9 , 2 2 9 . , a n d F r i e d m a n , S. ( 1 9 6 5 ) . Pharmacol. Rev. 1 7 , 7 1 . K i r p e k a r , S . M . , a n d Cervoni, P. ( 1 9 6 3 ) . / . Pharmacol. Exp. Ther. 1 4 2 , 5 9 . Klein, D .

Tyrsosine hydroxylase activity is present in the whole fetal rat brain (Table I) at 15 days of gestation with a specific activity of 7% of the adult level (Coyle and Axelrod, 1972b). Enzyme activity shows a triphasic increase in specific activity during development with a 4-fold rise between 15 and 18 days of gestation, then a period of relatively constant specific activity until 1 week after birth, and finally a linear increase to adult levels by 5-6 weeks after birth (Coyle and Axelrod, 1972b; Breese and Traylor, 1972).

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