By Shabir H. Lone, Khursheed Ahmad Bhat, Mohammad Akbar Khuroo
This publication reports the chemical and organic houses of Artemisia amygdalina Decne, a severely endangered and endemic plant species within the the high-altitude Kashmir Himalayas, which has a excessive pharmacological power. It describes the bioactivity-guided isolation of its chemical substances, their characterization utilizing spectroscopic equipment and the advance of an easy and trustworthy RP-HPLC technique for the simultaneous quantification of the remoted ingredients. The authors talk about the aptitude pharmacological actions of A. amygdalina, reminiscent of antioxidant, cytotoxic, anti inflammatory, immuno-modulatory and antidiabetic results, and pave the best way for destiny research.
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Additional resources for Chemical and Pharmacological Perspective of Artemisia amygdalina
Ii) The biological potential of the isolated chemical constituents from A. amygdalina Decne. (iii) The development and validation of an RP-HPLC method for simultaneous quantification of the chemical constituents of A. amygdalina Decne for use in herbal industry. 2 Phytochemistry Preliminary screening of hexane extracts has been carried out using SRB assay against human lung (A-549), colon (HCT-116), prostate (PC-3), and leukemia (THP-1) cell lines. 1) Both the hexane extracts of root and shoot showed potent cytotoxicity almost against all the tested cell lines.
36 integrating for three protons) confirmed methoxyl group forming the second terminus of the chain. All this data on comparison with previous literature reports (Greger 1978) confirmed 4 to be trans-matricaria ester. 09 [M + 1]+. IR absorption bands at 2217, 2140 (C≡C) and 1646 (C=C) cm−1 suggested the presence of ene–diyne unit. 68 corresponding to 4 acetylenic carbons. 18 (br s, 1H)] which is because of strong inductive and conjugative effects of oxygen atom and diacetylene group. 59 (6H, m) suggested the presence of a cyclic spiroacetal unit that is common in natural acetylenes (Liang et al.
Amygdalina according to the guidelines of the organisation for Economic Cooperation and Development (OECD 2008). The rats have been kept on fasting overnight, being provided only water prior to oral dosing. , 100, 200, 500, 1000, 1500, and 2000 mg/kg of body weight. The rats have been observed continuously for 24 h for behavioural and any adverse change and thereafter for any lethality. The extracts were found to be safe up to the dose level of 2000 mg/kg of body weight in rats. The extracts did not induce any toxicological effect in any rat.