By Usha Kasid, Robert Clarke
This quantity is a worthy and well timed source for a wide viewers with pursuits in simple and translational melanoma biology, melanoma drug improvement, in addition to within the perform of custom-made oncology. Written within the hugely winning equipment in Molecular Biology sequence structure, chapters comprise introductions to their respective subject matters, lists of the required fabrics and reagents, step by step, simply reproducible laboratory protocols, and pointers on troubleshooting and heading off recognized pitfalls.
Authoritative and state-of-the-art, Cancer Gene Networks goals to make sure profitable ends up in the additional learn of this evolving and important box. finally those efforts will advisor improvement of transformative recommendations for melanoma prognosis and treatment.
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Extra resources for Cancer Gene Networks
A frequently deleted locus on chromosome 10q24-25 has recently been shown to harbor the PTEN tumor suppressor gene [11, 12], thus supporting the concept of multiple candidate tumor suppressor genes in this region. The ANXA7 gene is located at human chromosome 10q21, and ANXA7 deletions are extremely common in human cancers, especially those that arise from prostate and breast. Four microsatellite markers at or near the ANXA7 locus on chromosome 10q21 were used to analyze the DNA from laser capture microdissected tumor cells and matched normal cells.
15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. Chuong Nguyen et al. mixtures using the stability of proteins from rates of oxidation. Nat Protoc 8:148–161 West GM, Tang L, Fitzgerald MC (2008) Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy. Anal Chem 80:4175–4185 Lomenick B, Olsen RW, Huang J (2011) Identification of direct protein targets of small molecules. ACS Chem Biol 6:34–46 Lomenick B, Hao R, Jonai N et al (2009) Target identification using drug affinity responsive target stability (DARTS).
While prostatic stem cells are located in the basal cell layer , the exact identity of the putative stem cells of the mammary gland remains a matter of investigation [50, 51]. Interestingly, ANXA7 has pro-apoptotic properties as compared to the apoptosis inhibiting function of Bcl2. The opposite role in apoptosis control of Bcl-2 and ANXA7 may explain their opposite expression pattern in benign prostate glands and prostate cancers (Table 1). In addition, loss of ANXA7 or overexpression of Bcl-2 leads to downregulation of IP3 Receptorregulated store-operated calcium channels.