Download Cancer Drug Discovery: Science and History by Kyu-Won Kim, Jae Kyung Roh, Hee-Jun Wee, Chan Kim PDF

By Kyu-Won Kim, Jae Kyung Roh, Hee-Jun Wee, Chan Kim

The reader will find a accomplished and multifaceted assessment of the historical past of the advance of anticancer medicines deeply prompted by way of the phone idea of melanoma and destiny instructions for the advance of latest anticancer medicinal drugs. First, this publication records the medical development in organic technology during the last 70 years and the effect this development had in melanoma study. Summaries and charts of vital discoveries whole this assessment. in addition, this booklet outlines the method of anticancer drug improvement with a spotlight at the attribute drug teams of every period, concerning developments of chemistry and organic sciences. This booklet additionally presents short mechanism of motion of gear, illustrated by means of complete timelines and conceptual cartoons. This booklet eventually sums up the restrictions of the present anticancer drug improvement and seeks new instructions for anticancer drug discovery, contemplating less than the systemic view of cancer.

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S. C. Virchow Blastema theory of cancer—Neoplasm R. C. A. H. 5 Advancement of science, history of cancer, and cancer drug development 44 Advancement of the Science and History of Cancer and Anticancer Drugs 1940 1938 [1931–1950] 1928 1927 1915 1909 1909 Introduction of the term “molecular biology” W. Weaver Purification of actinomycin D S. Waksman Discovery of penicillin, an antibiotic A. Fleming Discovery of Salvarsan, an antisyphilitic drug P. L. H. J. Müller 1937 1935 1914 1912 1910 1902 Discovery of tumor-causing papilloma virus P.

A. Weinberg Cancer: molecular alterations of genes B. Vogelstein 1982 1988 1986 1984 1983 1982 Discovery of Helicobacter pylori B. Marshall R.

Monod Discovery of DNA double helix J. Watson F. Crick Anticancer drug screening using mouse lymphoid leukemia cell line, L1210 1949 Link between smoking & lung cancer—propose primary prevention of cancer I. MacLeod Development of Pap smear method for cervical cancer screening G. Papanicolaou 1948 1954 Discovery of hormone dependence of prostate cancer C. Huggins 1941 History of cancer 1955 1951 1950 1948 1946 Development of prednisolone A. M. B. Elion Establishment of Cancer Chemotherapy National Service Center (CCNSC) Use of N-mustard to treat lymphoma A.

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