By Eric C. Schirmer, Jose I. de las Heras
This quantity brings jointly many alternative researchers and views masking the old and present use of the nuclear envelope in melanoma prognosis and grading, transparent and most likely appropriate capabilities of the nuclear envelope in phone cycler law and signaling, chromatin association and gene expression, genome balance, nucleocytoplasmic shipping, mobile mechanical balance and migration, in addition to unforeseen hyperlinks among the nuclear envelope and tumorigenesis.
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Extra info for Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes
1 Overview of reactivity of lamin antibodies in testicular germ cells. Note the prominent changes in lamin expression upon spermatogenesis. *epitope masking? Based on the more extensive studies in mouse tissues, it is likely that lamin B1 is also present in human sperm cell development this is not the case. To our knowledge only few studies have investigated lamin expression in germ-line tissues and tumors. In fact, only one study has been done on lamin expression in testis and testis tumors using human material .
In 1984 Bob Goldman’s laboratory isolated lamins from cultured cells and characterized them as keratin-like proteins, but did not himself realize that they were from the protein polymer underlying the inner nuclear membrane . Finally in 1986 Frank McKeon, Marc Kirschner, and Daniel Caput  and Daniel Fisher, Nilabh Chaudhary, and Gunter Blobel  separately identiﬁed the lamins as intermediate The Nuclear Envelope and Cancer: A Diagnostic Perspective… 17 ﬁlament proteins. As such, the lamins have short N-terminal head domains (~33 amino acids) followed by a long rod domain (~350 amino acids) that homodimerizes to form four separate coiled coils separated by linkers for a linear length of ~52 nm followed by a large globular and variable C-terminal domain.
62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. 76. I. C. Schirmer morphometry of cytology samples obtained by ﬁne-needle aspiration: preliminary report. Head Neck 35(1):28–34. 22909 Helander K, Hofer PA, Holmberg G (1984) Karyometric investigations on urinary bladder carcinoma, correlated to histopathological grading. Virchows Arch A Pathol Anat Histopathol 403(2):117–125 van Velthoven R, Petein M, Oosterlinck WJ, Zandona C, Zlotta A, Van der Meijden AP, Pasteels JL, Roels H, Schulman C, Kiss R (1995) Image cytometry determination of ploidy level, proliferative activity, and nuclear size in a series of 314 transitional bladder cell carcinomas.