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Increased serum fucosyltransferase, decreased sialyl- and galactosyl-transferases in breast carcinoma Chatterjee 1978. Decreased glycoprotein synthesis in human colon cancer O'Gorman & La Mont, 1978. Decreased microsomal glycosyltransferases in human and experimental colon cancer Freeman, et al, 1978. Decreased glycoprotein synthesis (mucus) in human gastric cancer Parke & Symons, 1977. Cell surface glycoprotein profile in classification of leukaemia Anderson, et al, 1979. Increased sialic acid content of rat liver S-glucuronidase in malignant tumours Harris, et al, 1980.

Biophys. Res. , 73:459. O'Connor, P. , and Margison, G. , 1979, ~-Nitroso­ compounds: Biochemical mechanisms of action, in: "Environmental Carcinogenesis: Occurrence, Risk Evaluation, ana Mechanisms," P. Emmelot and E. , p. 73, Elsevier/North Holland, Amsterdam. , 1973, Mammalian epoxide hydrases: Inducible enzymes catalyzing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds, 20 E. MILLER AND J. MILLER Xenobiotica, 3:305. Oswald, E. , Corbett, B.

39 9. 8. 7. 6. 5. 4. 3. 2. 1. No. 9 2 99 69 9 7 < 0. 3 c€~t'] ~co,a''] ~OH B, ~H ~8· e. 7 < 126 128 < 0. 6 TA his+ revertant colonies per ~mol in strain a l~utagenicity is reported in terms of his+ revertants (minus spontaneous rate of mutation) per ~mol of compound. These values are taken from the linear region of the dose-response curve. The following numbers of colonies per plate above spontaneous mutations were considered to be significant for mutagenicity in the respective strains: > 20 (TA 98, TA 1535), > 40 (TA 100).

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