By Jae Y. Ro MD PhD, David J. Grignon MD, Alberto G. Ayala MD
This newest quantity within the Atlases in Diagnostic Surgical Pathology sequence enables the identity of ailments of the male genitourinary tract. Lavishly illustrates a extensive variety of universal and strange stipulations affecting the prostate, seminal vesicles, testes, penis, and scrotum. additionally contains illustrations of complementary histochemical and immunohistochemical reviews the place acceptable.
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Extra info for Atlas of surgical pathology of the male reproductive tract
Arcl1 Parhol Lab Med 119:444-447 , 1995 HI GH-M OLECULAR- W EIGHT CY TOKERATTN ( HMWK) • Expression of HMWK is restricted to prostatic basal cells; it is not present in secretory cells. • Several studies have documented the usefulness of this test in confirming the absence of basal cells in cancer, and the presence of basal cells in benign small acinar lesions. • The clone most frequently used is 34~E12 (CK903 , a catalogue number, has frequently been used to refer to a specific commercially available antibody).
This pattern is common in transition zone adenocarcinomas , but much less frequ ent in peripheral zone cancers. The presence of even a few well -fo rmed mal ignant glands in a needl e biopsy (often interspersed amo ng be nign elements) indicates a grade 3 pattern and is not indicative of grades 1 or 2. Grade 3 Ineludes three distinct architectural patterns . Most common are well-formed , relative ly uniform glands growing in an infiltrative manner; growth betwee n benign g lands is a useful clue to th is grade.
Compression (atroph y) of peripheral zone. Mt CROSCOl'lC • Well -circum. cribed, noneneapsulated, ex pansiJc nodules . • 80lh ep ithelial and stromal eomponen ts participate in varyin g proportions. u larly shaped glands with undulating profile. • lnvaginations ("papillae") ha ve central fibrovaseular core. Fig ul'c 2--33. Atrop hy. Focus 01" atrnp hy (righ t) infilLrated by Glra,on grade 3 ade nocarci noma . : i, and prominent nucleoli in the mali gnan t glands compared with the atrophi c gland s.