By B J A Furr
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Additional info for Aromatase inhibitors
3365s–3368s 63 Peice T, Aitken J, Head J, Mahendroo M, Means G, Simpson E (1992) Determination of aromatase cytochrome P-450 messenger ribonucleic acid in human breast tissue by competitive polymerase chain reaction amplification. J Clin Endocrinol Metab 174: 1247–1252 64 Koos RD, Banks PK, Inkster SE, Yue W, Brodie AMH (1993) Detection of aromatase and keratinocyte growth factor expression in breast tumors using reverse transcription-polymerase chain reaction. J Steroid Biochem Mol Biol 45: 217–225 65 Lu Q, Nakamura J, Savinov A, Yue W, Weisz J, Dabbs DJ et al.
Based on these results, it seems likely that aromatase inhibitors, even in long-term use, will not cause stimulation of the endometrium as reported in some women receiving tamoxifen. In recent clinical trials, no adverse effects on the endometrium have been observed in patients treated with the aromatase inhibitors letrozole, anastrozole, and exemestane [31, 34, 35]. Sequential treatment with aromatase inhibitors and antioestrogens We observed previously that switching mice treated first with tamoxifen to second-line treatment with letrozole was effective in slowing tumour growth compared to continuing treatment with tamoxifen .
Proteins in the lysates were separated on a denaturing polyacrylamide gel and transferred to a nitrocellulose membrane. 1% Tween 20 in PBS (PBS-T) and 5% non-fat dried milk to block non-specific binding to antibodies. The membranes were then incubated with respective primary antibodies in PBS-T milk for 1 h, and specific binding was visualized by using species-specific IgGs followed by enhanced chemiluminescence detection (ECL kit; Amersham Biosciences) and exposure to ECL X-ray film. Interestingly, expression of erbB2 was increased in both cell lines compared to MCF-7CA cells as well as in letrozole-treated tumours, as indicated above.