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By M. Brouwer, W.E.S. Carr, W. Ross Ellington, D.W. Engel, R.A. Gleeson, B. Korsgaard, T.S. Moerland, T. Mustafa, D.J. Prior, B.D. Sidell, K.C. Srivastava, H.G. Trapido-Rosenthal, R.E. Weber, R.W. Wiseman

Advances in Comparative and Environmental Physiology is helping biologists, physiologists, and biochemists continue song of the large literature within the box. offering finished, built-in experiences and sound, serious, and provocative summaries, this sequence is a must for all energetic researchers in environmental and comparative physiology.

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References ................................................................... 25 29 29 32 35 35 36 36 38 40 41 42 42 45 1 Introduction The presence of specific chemical substances in the environment evokes behavioral responses in many lower eukaryotic organisms such as protozoans and invertebrates (for reviews, see Mackie and Grant 1974, Gleeson 1978, Atema 1985, Carr 1987). Beginning with Haldane (1954), investigators have noted that several of the chemical substances evoking these responses in lower life forms include some of the very same compounds that function internally as neurotransmitters, modulators, or hormones (see Thble 1).

25 29 29 32 35 35 36 36 38 40 41 42 42 45 1 Introduction The presence of specific chemical substances in the environment evokes behavioral responses in many lower eukaryotic organisms such as protozoans and invertebrates (for reviews, see Mackie and Grant 1974, Gleeson 1978, Atema 1985, Carr 1987). Beginning with Haldane (1954), investigators have noted that several of the chemical substances evoking these responses in lower life forms include some of the very same compounds that function internally as neurotransmitters, modulators, or hormones (see Thble 1).

1985) Mitchell (1976) Chase and Wells (1986) Mackie and Adron (1978) Kiyohara et aI. (1975) Boudreau et aI. (1975) Boudreau (1987) Torii and Cagan (1980) Yamaguchi (1979) Rifkin and Bartoshuk (1980) Schiffman et aI. (1985) Within the past 20 years adenosine and its noncyclic nucleotides have been implicated as important neurotransmitter/modulator substances in mammalian species. Receptors for these compounds (purinergic receptors) have been identified in a variety of tissues including central and peripheral neurons (Burnstock 1980; Phillis and Wu 1981), smooth muscle cells of the viscera (Brown and Burnstock 1981), and components of the cardiovascular system (Olsson et al.

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