By Qingming Luo, Lihong V. Wang, Valery V. Tuchin
Read or Download Advances in Biomedical Photonics and Imaging: Proceedings of the 6th International Conference on Photonics and Imaging in Biology and Medicine (Pibm 2007) Wuhan, P R China, 4-6 November 2007 PDF
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Extra info for Advances in Biomedical Photonics and Imaging: Proceedings of the 6th International Conference on Photonics and Imaging in Biology and Medicine (Pibm 2007) Wuhan, P R China, 4-6 November 2007
13. 14. 15. 16. 17. 18. 19. 20. 21. 22. Z. Huang, Technol. Cancer Res. Treat. 4, 283 (2005). H. Selman, Photodiag. Photodyn. Ther. 4, 26 (2007). J. C. Wilson, Lasers Surg. Med. 38, 384 (2006). Z. Huang, Photodiag. Photodyn. Ther. 3, 71 (2006). M. Biel, Lasers Surg. Med. 38, 349 (2006). G. 3-8. Harwood Academic Publishers, London (1997). M. Loewen, R. Pandey, D. Bellnier, B. Henderson and T. Dougherty, Lasers Surg. Med. 38, 364 (2006). J. Jankun, L. Lilge, A. Douplik, et al. J. Urol. 172, 739 (2004).
4. Tissue Oxygenation The effectiveness of PDT is determined by many factors. Besides intrinsic target tissue sensitivity to ROS, the other important factors include concentration of the sensitizer, absorption of light energy, and availability of molecular oxygen in the target tissue during light irradiation. The availability of molecular oxygen during irradiation has a profound effect on the treatment outcome. It can be summarized as without oxygen, PDT will have literally no antitumor effect.
The vascular network of the PA reconstructed image is in excellent agreement with the open-skull anatomical photograph Fig. 4(b). This experiment testified that PAI has the ability for noninvasively imaging of brain cortical vasculature. Figure 4. PA images of mouse brain in vivo. (a) Noninvasive image of a mouse brain acquired using the PAI system with the skin and skull intact. Detailed brain tissue structures: CB, cerebellum; BV, blood vessel; LH, left hemisphere; LOB, left olfactory lobe; MCA, middle cerebral artery; RH, right hemisphere; and ROB, right olfactory lobe.