By H. Arnouk
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Extra info for Advancements in Tumor Immunotherapy, Cancer Vaccines
Food and Drug Administration’s fast track for approval. 2 Viral vector-based immunotherapy Treatment options for advanced metastatic disease, particularly in renal cancer, are highly toxic with few clinical benefits. Researchers are focusing on new options that produce therapeutic potential while providing a favorable toxicity profile. The use of viral vectors has been explored to promote an immune response against target antigens. The primary focus of viral vectors is identifying optimal tumor-associated antigens and finding a suitable delivery system.
Pre-existing T-cell proliferation responses to GM-CSF were observed in 57% patients, which increased after treatment with Provenge to a total 70% of patients. Overall treatment was well tolerated; most patients had no treatment-related adverse events. Three patients had a more than 50% decline in serum prostate-specific antigen (PSA) level, and another three patients had 25% to 49% decreases in PSA levels. , 2000). , 2004), 21 patients with histologically documented androgen-independent prostate carcinoma were enrolled.
Most treatment for bladder cancer has focused on the use of Bacille Calmette-Guerin following resection. Multiple studies have established that treating bladder cancer with a complete transurethral resection or fulguration of superficial disease followed by Bacille CalmetteGuerin prophylaxis significantly reduces recurrence and prolongs disease-free progression in comparison to transurethral resection alone (Lamm, 1992). , 1996). One study of patients with T1 lesions who were treated with Bacille Calmette-Guerin following transurethral resection found that 91% of patients were free of tumor recurrence for a mean follow up of 59 months.